PRP, Hormone, & Stem Cell Research and Therapy | RestorePDX

Research Papers

Percutaneous Injection of Autologous Bone Marrow Concentrate Cells Significantly Reduces Lumbar Discogenic Pain through 12 Months

Degenerative disc disease is a progressive deterioration of intervertebral discs causing a loss of disc height and pain. Back pain affects millions of Americans and results in billions of dollars in lost income and medical expenses annually. In fact, degenerative changes in lumbar discs are so ubiquitous that they are considered “a normal aging process,” as documented in several magnetic resonance imaging (MRI) scan studies [1–3]. However, the exact cause of disc degeneration is complicated. Various animal studies have been contradictory in directly correlating biomechanical stress and disc degeneration [4–11]. Likewise, published clinical studies have failed to link disc degeneration directly to mechanical factors such as labor‐intensive [12,13]. As a further complication, the perception of pain in humans is complex, related to psychosocial factors, environmental factors and one’s perception of life’s satisfaction [12–19]Read More »

The effects of repeated intra-articular PRP injections on clinical outcomes of early osteoarthritis of the knee.

Intra-articular PRP injections into the knee for symptomatic early stages of OA are a valid treatment option. There is a significant reduction in pain and improvement in function after 12 months, which can be further improved at 18 months by annual repetition of the treatment. Although the beneficial effects are ill sustained at 2 years, the results are encouraging when compared to the pre-treatment function. Read More »

Are Multiple Platelet-Rich Plasma Injections Useful for Treatment of Chronic Patellar Tendinopathy in Athletes? 

Chronic patellar tendinopathy, also called jumper’s knee, is a common disease characterized by pain, swelling, and reduced load-bearing capacity. It occurs mostly in athletes but can also occur in sedentary people. Jumper’s knee is the most common injury in sports, characterized by high demand on the knee extensors for speed and power. Forty percent of professional players have experienced symptoms of this condition during their career. This tendinopathy affects athletes in many sports: volleyball (40%), basketball (35%), soccer, jumping, and sprinting. In a prospective 15-year follow-up study, Kettunen et al found that chronic patellar tendinopathy commonly leads to athletes abandoning their careers and causes mild but long-lasting symptoms after their careers. Read More »

Could platelet rich plasma (PRP) have effects on systemic circulating growth factors and cytokine release in orthopaedic applications?

The use of platelet rich plasma (PRP) has been proposed for tendon and ligament healing. The rationale is the release of large amounts of growth factors and cytokines with regenerative, anabolic, and anti-inflammatory effects on damaged tissues.1–3

We applied PRP in tendinopathies of professional athletes. PRP was obtained using the gravitational platelet separation system GPS II (Biomet, Bridgend, Wales, UK) from 30 ml peripheral anticoagulated whole blood, and introduced by a syringe to multiple sites of injured tendon. Read More »